It's just Seth MacFarlane trying to cram as many references to pop culture as he possibly can hoping that it will appear fresh and appeal to the audience of brainless freaking organbanks that like the show.
First 2 Seasons were nothing but "Like the time I..." joke set ups. They were unfunny then and they still are now.
All the while the show has gone downhill American Dad has distanced itself from all that pop-culture esque bullshit and turned into an almost reasonably good show.